HIV-1-Based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions
A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T cell welding sweater responses would be optimal for preventing HIV-1 transmissions.Replication incompetent HIV-1 virus-like particles (VLPs) offer the opportunity to present authentic-structured, virion-associated Env to